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Figure 1 | Molecular Pain

Figure 1

From: NAAG peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model of inflammation

Figure 1

a: NAAG immunoreactivity in neurons and processes of the lateral periaqueductal gray (PAG). Regions denoted with letters in panel A show the areas of enlargement found in panels B – D. NAAG staining was relatively light in the region immediately surrounding the cerebral aqueduct (AQ), which contained small NAAG stained neurons and fine immunoreactive fibers (arrows in B). More neurons and processes were strongly immunoreactive for NAAG at the periphery of the PAG (C and D). The finely punctate staining represents high concentrations of NAAG as would be found in synaptic endings. Bar = 15 μm B – D. b: NAAG immunoreactivity in the raphe magnus (RM) of the brainstem (A). NAAG staining in the RM was similar to adjacent reticular areas with numerous moderately to strongly immunoreactive neurons. Many neuronal processes were immunoreactive for NAAG in the RM (B). Bar = 30 μm in B. c: NAAG-immunoreactivity in apparent synaptic contacts on neurons in the lateral PAG. Areas within boxes in A and C are enlarged in B and D. Panel A is from a region immediately adjacent to the cerebral aqueduct and Panel C is slightly further from the aqueduct. Apparent NAAG-containing synaptic contacts were observed on the surface of perikarya, major dendrites, and in the neuropil. Images acquired with extended depth of field. Bar = 5 μm B and D.

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Molecular Pain

ISSN: 1744-8069

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